Polysynaptic reflexes involve synapses on both sides.

• A. True
• B. False
• C. Not specified
• D. Rarely

Answer: (A)

Polysynaptic reflexes rely on interneurons in the spinal cord that create more than one synapse between the sensory input and the motor output. This setup allows the nervous system to coordinate more complex responses, including actions across limbs. A key reason they’re often described as involving synapses on both sides is the presence of commissural interneurons that cross the midline to influence the opposite side. For example, the withdrawal reflex in one leg is frequently accompanied by adjustments in the opposite leg to maintain balance, mediated by these cross-midline connections. So, the bilateral coordination seen in many polysynaptic reflexes makes the statement true: they typically involve multiple synapses and often engage both sides of the body.